解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
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公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Fetal alcohol exposure in human and rodents produces a number of cognitive deficits including impairments in learning and memory. Recent evidence in our laboratory has shown that fetal alcohol-exposed (FAE) rats respond differently to systemic administration of cholinergic drugs when tested for vigilance and locomotor...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1999.3909
更新日期:1999-11-01 00:00:00
abstract::The neurophysiological basis for context conditioning is conceptually problematic because neurophysiological descriptions of activity-dependent (associative) forms of neuronal plasticity uniformly assume that a specific temporal relationship between signals is necessary for memory induction. In the present experiments...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1998.3890
更新日期:1999-09-01 00:00:00
abstract::Extensive evidence indicates that benzodiazepine receptors in the amygdala are involved in regulating memory consolidation. Recent findings indicate that many other drugs and hormones influence memory through selective activation of the basolateral amygdala nucleus (BLA). This experiment examined whether the memory-mo...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1999.3912
更新日期:1999-07-01 00:00:00
abstract::The immunotoxin 192-saporin, infused intracerebroventricularly into rats, destroys cholinergic neurons in the basal forebrain nuclei. Doses required for complete cholinergic loss also kill some Purkinje cells. The immunotoxin OX7-saporin, when infused intraventricularly into rats, destroys Purkinje cells in a pattern ...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1998.3884
更新日期:1999-05-01 00:00:00
abstract::Attempts were made to further analyze the role of 5-HT1A receptors in consolidation of learning by evaluating the role of these receptors in cognitively normal and impaired animals. The effects of post-training administration of 8-OH-DPAT and 5-HT1A receptor antagonists, WAY 100135, WAY 100635, and S-UH-301, plus the ...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1998.3866
更新日期:1999-03-01 00:00:00
abstract::In a previous study, adult male Sprague-Dawley rats with unilateral, electrolytic entorhinal cortex lesions showed significant deficits in acquisition of a water maze task that measured working memory. The 10 days of testing used two trials per day with an intertrial interval of 1 h, and the rats with entorhinal damag...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1998.3832
更新日期:1999-01-01 00:00:00
abstract::The efficacy of synaptic transmission between two neurons changes as a function of the history of previous activations of the synaptic connection. This history dependence can be characterized by examining the dependence of transmission on the frequency of stimulation. In this framework synaptic plasticity can also be ...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1998.3841
更新日期:1998-07-01 00:00:00
abstract::Complex motor skill learning, but not mere motor activity, leads to an increase in synapse number within the cerebellar cortex. The present experiment used quantitative electron microscopy to determine which synapse types were altered in number. Adult female rats were allocated to either an acrobatic condition (AC), a...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1998.3827
更新日期:1998-05-01 00:00:00
abstract::The effects of morphine (6.3, 12.6, and 25.2 mg/kg) on active avoidance behavior of BALB/C mice are explored in three acquisition sessions and in two subsequent performance sessions. Morphine-treated animals showed an increase in avoidance acquisition with respect to control group without differences in performance. H...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1997.3804
更新日期:1998-03-01 00:00:00
abstract::Recent data have demonstrated a biochemical sequence of events in the rat hippocampus that is necessary for memory formation of inhibitory avoidance behavior. The sequence initially involves the activation of three different types of glutamate receptors followed by changes in second messengers and biochemical cascades...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章,评审
doi:10.1006/nlme.1997.3799
更新日期:1997-11-01 00:00:00
abstract::Three experiments studied the effectiveness of ketamine acting as an aversive unconditioned stimulus (UCS) in a conditioned flavor aversion procedure. In Experiment 1a, three conditioning trials where sucrose was paired with ketamine produced a weak but significant aversion to sucrose; Experiment 1b showed that this e...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1997.3773
更新日期:1997-09-01 00:00:00
abstract::Place navigation engrams acquired with intact brain can be retrieved with either eye and are stored in both hemispheres. The retrieval circuitry was examined by testing an overtrained rat under lidocaine inactivation of the hippocampus, visual cortex, and superior colliculus. Thirty-three hooded rats with implanted ca...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1997.3771
更新日期:1997-07-01 00:00:00
abstract::The effects of selective cholinergic cell loss within the basal forebrain (BF) were determined using a task that requires shifting of attention between two visual stimuli. Discriminability between two stimuli and response bias were determined in young and old F-344 rats given BF injections of IgG-192 saporin (100 ng)....
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1997.3768
更新日期:1997-05-01 00:00:00
abstract::The impact of past history on behavior across the life span is largely unknown. This is why the role of previous experience in subsequent memory performances has been studied in a combined longitudinal (animals repeatedly tested) and cross-sectional (animals tested once at various ages) study, in male Sprague-Dawley r...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1996.3750
更新日期:1997-03-01 00:00:00
abstract::In order to study the effects of differential housing conditions on recovery from damage to different components of the hippocampal formation, 85 rats received bilateral lesions of the hippocampus, entorhinal cortex, or subiculum or sham surgery and then were housed for 30 days in either an enriched environment or an ...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1996.3745
更新日期:1997-01-01 00:00:00
abstract::It has been known for a long time that cholinergic basal forebrain neurons which project to the cerebral cortex play a role in learning and memory. Behavioral studies following lesions, for example, repeatedly have suggested multiple learning-related roles for these neurons. Apart from behavioral studies, cholinergic ...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1996.0068
更新日期:1996-11-01 00:00:00
abstract::The present experiments examined the effects of posttraining intra-dorsal striatal (i.e., caudate-putamen) injections of the phospholipid methylcarbamyl platelet-activating factor (mc-PAF) and the platelet-activating factor (PAF) antagonist BN 52021 on memory using a striatal-dependent cued water maze task. Male Long-...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1996.0058
更新日期:1996-09-01 00:00:00
abstract::In this study, we evaluated the effects of NMDA-induced lesions in different sites of the insular cortex of the rat on the acquisition of conditioned taste aversion and spatial learning in the Morris water maze. The lesions were produced by bilateral microinjections of NMDA in the insular cortex at +3.7 mm (Anterior g...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1996.0042
更新日期:1996-07-01 00:00:00
abstract::Adult Aplysia exhibit both short-term and long-term memory for sensitization in the gill and siphon withdrawal reflex. Previous developmental studies showed that short-term memory for sensitization emerges late in juvenile development (stage 12; Rankin and Carew, 1988; Wright et al., 1991). In the present study, we ex...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1996.0031
更新日期:1996-05-01 00:00:00
abstract::Cerebellar damage occurs during developmental stages in three mutant mice (staggerer, hot-foot, and lurcher), causing disturbances in posture and equilibrium. During three tests of motor coordination, the performances of staggerer mutants was inferior to that of normal mice and did not improve with extended practice f...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1996.0013
更新日期:1996-03-01 00:00:00
abstract::The dynamics of learning in the Active Avoidance test was analyzed at the trials level as well as at the level of daily sessions, each comprising numerous trials. The two scales (large scale for the sessions and small scale for the trials) were demonstrated to be mutually independent. The intermediate derived scales (...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1996.0009
更新日期:1996-01-01 00:00:00
abstract::The two main objectives of this study were (1) to replicate previous findings that 6 days of binge-like exposure to alcohol during the neonatal brain growth spurt induces significant place learning deficits in juvenile rats and (2) to determine whether more limited (3-day) binge-like exposure during the neonatal perio...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1995.0009
更新日期:1995-11-01 00:00:00
abstract::Two experiments examined the effects of total stimulus preexposure on latent inhibition (LI) in a conditioned taste aversion procedure with rats. Experiment 1 varied the frequency and duration of saccharin preexposures. LI was an increasing function of the product of frequency x duration. Experiment 2 kept saccharin e...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1995.1051
更新日期:1995-09-01 00:00:00
abstract::Evidence indicating a role for the nucleus accumbens in the development of latent inhibition of learning has accumulated. Two experiments were conducted using Wistar rats to investigate this role directly. Experiment 1 used a conditioned emotional response paradigm to assess the effects of discrete electrolytic lesion...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1995.1042
更新日期:1995-07-01 00:00:00
abstract::The hypotheses that the medial septal area (MSA) is critical for working memory and that MSA neural activity is positively regulated by cholinergic inputs leads to two testable predictions: (1) working memory can be bidirectionally modulated by muscarinic manipulations of the MSA and (2) muscarinic activation of the M...
journal_title:Neurobiology of learning and memory
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1006/nlme.1995.1031
更新日期:1995-05-01 00:00:00
abstract::Rats were trained to run on a staircase stopping on the 3rd, 6th, 9th, and 12th steps (correct responses). Stopping on any other step was considered an error. Acute administration of 0.5 mg/kg of arecoline 15 min before the trial improved behavior and 3.5 mg/kg of arecoline caused a reduction of correct responses. An ...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1995.1017
更新日期:1995-03-01 00:00:00
abstract::The protein product of the immediate-early gene, c-fos, was visualized immunocytochemically in forebrain neurons of gonadectomized male and female rats which were injected daily with testosterone propionate (TP) and either tested for mounting directed toward a sexually receptive female or left alone in a test arena. L...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1995.1006
更新日期:1995-01-01 00:00:00